1 | import org.codehaus.groovy.grails.commons.GrailsApplication |
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2 | import grails.util.GrailsUtil |
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3 | import dbnp.studycapturing.* |
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4 | |
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5 | import dbnp.data.Ontology |
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6 | import dbnp.data.Term |
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7 | import java.text.SimpleDateFormat |
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8 | |
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9 | /** |
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10 | * Application Bootstrapper |
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11 | * @Author Jeroen Wesbeek |
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12 | * @Since 20091021 |
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13 | * |
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14 | * Revision information: |
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15 | * $Rev: 269 $ |
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16 | * $Author: keesvb $ |
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17 | * $Date: 2010-03-15 21:40:37 +0000 (ma, 15 mrt 2010) $ |
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18 | */ |
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19 | class BootStrap { |
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20 | def init = {servletContext -> |
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21 | // define timezone |
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22 | System.setProperty('user.timezone', 'CET') |
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23 | |
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24 | // we could also check if we are in development by GrailsUtil.environment == GrailsApplication.ENV_DEVELOPMENT |
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25 | if (Study.count() == 0) { |
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26 | printf("development bootstrapping....\n\n"); |
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27 | |
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28 | // ontologies |
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29 | def speciesOntology = new Ontology( |
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30 | name: 'NCBI Taxonomy', |
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31 | shortName: 'Taxon', |
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32 | url: 'http://www.obofoundry.org/cgi-bin/detail.cgi?id=ncbi_taxonomy' |
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33 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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34 | |
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35 | def humanBodyOntology = new Ontology( |
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36 | name: 'Foundational Model of Anatomy', |
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37 | shortName: 'HumanBody', |
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38 | url: 'http://bioportal.bioontology.org/ontologies/39966' |
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39 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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40 | |
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41 | // terms |
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42 | def mouseTerm = new Term( |
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43 | name: 'Mus musculus', |
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44 | ontology: speciesOntology, |
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45 | accession: '10090' |
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46 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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47 | def humanTerm = new Term( |
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48 | name: 'Homo sapiens', |
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49 | ontology: speciesOntology, |
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50 | accession: '9606' |
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51 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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52 | |
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53 | def bloodTerm = new Term( |
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54 | name: 'Portion of blood', |
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55 | ontology: humanBodyOntology, |
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56 | accession: '9670' |
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57 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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58 | |
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59 | def madmaxOntology = new Ontology( |
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60 | name: 'Madmax ontology', |
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61 | shortName: 'MDMX', |
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62 | url: 'madmax.bioinformatics.nl' |
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63 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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64 | |
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65 | def treatmentTerm = new Term( |
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66 | name: 'ExperimentalProtocol', |
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67 | ontology: madmaxOntology, |
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68 | accession: 'P-MDMXGE-264' |
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69 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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70 | |
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71 | def dietProtocol = new Protocol( |
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72 | name: 'Diet treatment Protocol NuGO PPS3 leptin module', |
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73 | reference: treatmentTerm |
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74 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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75 | |
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76 | def boostProtocol = new Protocol( |
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77 | name: 'Boost treatment Protocol NuGO PPS3 leptin module', |
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78 | reference: treatmentTerm |
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79 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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80 | |
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81 | def fastingProtocol = new Protocol( |
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82 | name: 'Fasting', |
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83 | reference: treatmentTerm |
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84 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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85 | |
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86 | |
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87 | // ParameterStringListItems |
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88 | def oil10= new ParameterStringListItem( |
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89 | name: '10% fat (palm oil)' |
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90 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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91 | def oil45= new ParameterStringListItem( |
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92 | name: '45% fat (palm oil)' |
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93 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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94 | def vehicle= new ParameterStringListItem( |
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95 | name: 'Vehicle' |
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96 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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97 | def leptin= new ParameterStringListItem( |
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98 | name: 'Leptin' |
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99 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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100 | |
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101 | |
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102 | dietProtocol |
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103 | .addToParameters(new ProtocolParameter( |
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104 | name: 'Diet', |
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105 | type: ProtocolParameterType.STRINGLIST, |
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106 | listEntries: [oil10,oil45])) |
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107 | .save() |
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108 | |
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109 | boostProtocol |
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110 | .addToParameters(new ProtocolParameter( |
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111 | name: 'Compound', |
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112 | type: ProtocolParameterType.STRINGLIST, |
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113 | listEntries: [vehicle,leptin])) |
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114 | .save() |
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115 | |
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116 | fastingProtocol |
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117 | .addToParameters(new ProtocolParameter( |
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118 | name: 'Fasting period', |
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119 | type: ProtocolParameterType.STRING)) |
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120 | .save() |
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121 | |
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122 | |
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123 | // sampling event protocols |
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124 | |
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125 | def liverSamplingProtocol = new Protocol( |
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126 | name: 'Liver sampling' |
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127 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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128 | |
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129 | liverSamplingProtocol |
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130 | .addToParameters(new ProtocolParameter( |
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131 | name: 'Sample weight', |
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132 | unit: 'mg', |
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133 | type: ProtocolParameterType.FLOAT)) |
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134 | .save() |
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135 | |
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136 | def bloodSamplingProtocol = new Protocol( |
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137 | name: 'Blood sampling' |
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138 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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139 | |
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140 | bloodSamplingProtocol |
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141 | .addToParameters(new ProtocolParameter( |
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142 | name: 'Sample volume', |
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143 | unit: 'ml', |
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144 | type: ProtocolParameterType.FLOAT)) |
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145 | .save() |
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146 | |
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147 | // create system user |
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148 | |
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149 | /*def systemUser = userService.createUser(InstanceGenerator.user( |
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150 | username: 'system', |
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151 | pass: 'system', |
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152 | passConfirm: 'system', |
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153 | enabled: true |
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154 | ))*/ |
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155 | |
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156 | |
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157 | def genderField = new TemplateField( |
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158 | name: 'Gender',type: TemplateFieldType.STRINGLIST, |
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159 | listEntries: [new TemplateFieldListItem(name:'Male'),new TemplateFieldListItem(name: 'Female')]) |
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160 | .with { if (!validate()) { errors.each { println it} } else save()} |
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161 | |
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162 | def ageField = new TemplateField( |
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163 | name: 'Age (years)',type: TemplateFieldType.INTEGER,unit: 'years') |
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164 | .with { if (!validate()) { errors.each { println it} } else save()} |
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165 | |
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166 | // Nutritional study template |
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167 | |
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168 | println "Adding academic study template..." |
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169 | def studyTemplate = new Template( |
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170 | name: 'Academic study', entity: dbnp.studycapturing.Study) |
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171 | .addToFields(new TemplateField(name: 'Consortium',type: TemplateFieldType.STRING)) |
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172 | .addToFields(new TemplateField(name: 'Cohort name',type: TemplateFieldType.STRING)) |
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173 | .addToFields(new TemplateField(name: 'Time zone',type: TemplateFieldType.STRING)) |
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174 | .addToFields(new TemplateField(name: 'Responsible scientist',type: TemplateFieldType.STRING)) |
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175 | .addToFields(new TemplateField(name: 'Lab code',type: TemplateFieldType.STRING)) |
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176 | .addToFields(new TemplateField(name: 'Institute',type: TemplateFieldType.STRING)) |
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177 | .with { if (!validate()) { errors.each { println it} } else save()} |
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178 | |
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179 | // Mouse template |
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180 | def mouseTemplate = new Template( |
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181 | name: 'Mouse', entity: dbnp.studycapturing.Subject) |
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182 | .addToFields(new TemplateField( |
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183 | name: 'Strain', type: TemplateFieldType.ONTOLOGYTERM)) |
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184 | .addToFields(new TemplateField( |
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185 | name: 'Genotype', type: TemplateFieldType.STRING)) |
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186 | .addToFields(new TemplateField( |
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187 | name: 'Genotype type',type: TemplateFieldType.STRINGLIST, |
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188 | listEntries: [new TemplateFieldListItem(name:'transgenic'),new TemplateFieldListItem(name:'knock-out'),new TemplateFieldListItem(name:'knock-in')])) |
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189 | .addToFields(genderField) |
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190 | .addToFields(new TemplateField( |
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191 | name: 'Age (weeks)', type: TemplateFieldType.INTEGER, unit: 'weeks')) |
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192 | .addToFields(new TemplateField( |
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193 | name: 'Age type',type: TemplateFieldType.STRINGLIST, |
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194 | listEntries: [new TemplateFieldListItem(name:'postnatal'),new TemplateFieldListItem(name:'embryonal')])) |
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195 | .addToFields(new TemplateField( |
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196 | name: 'Cage',type: TemplateFieldType.STRING)) |
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197 | .addToFields(new TemplateField( |
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198 | name: '#Mice in cage',type: TemplateFieldType.INTEGER)) |
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199 | .addToFields(new TemplateField( |
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200 | name: 'Litter size',type: TemplateFieldType.INTEGER)) |
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201 | .addToFields(new TemplateField( |
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202 | name: 'Weight (g)', type: TemplateFieldType.DOUBLE, unit: 'gram')) |
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203 | .addToFields(new TemplateField( |
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204 | name: 'SomeOntology', type: TemplateFieldType.ONTOLOGYTERM)) |
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205 | .with { if (!validate()) { errors.each { println it} } else save()} |
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206 | |
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207 | // Human template |
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208 | def humanTemplate = new Template( |
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209 | name: 'Human', entity: dbnp.studycapturing.Subject) |
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210 | .addToFields(genderField) |
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211 | .addToFields(ageField) |
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212 | .addToFields(new TemplateField( |
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213 | name: 'DOB',type: TemplateFieldType.DATE)) |
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214 | .addToFields(new TemplateField( |
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215 | name: 'Height',type: TemplateFieldType.DOUBLE, unit: 'm')) |
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216 | .addToFields(new TemplateField( |
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217 | name: 'Weight (kg)',type: TemplateFieldType.DOUBLE, unit: 'kg')) |
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218 | .addToFields(new TemplateField( |
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219 | name: 'BMI',type: TemplateFieldType.DOUBLE, unit: 'kg/m2')) |
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220 | .addToFields(new TemplateField( |
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221 | name: 'Race',type: TemplateFieldType.STRING)) |
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222 | .addToFields(new TemplateField( |
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223 | name: 'Waist circumvence',type: TemplateFieldType.FLOAT, unit: 'cm')) |
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224 | .addToFields(new TemplateField( |
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225 | name: 'Hip circumvence',type: TemplateFieldType.FLOAT, unit: 'cm')) |
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226 | .addToFields(new TemplateField( |
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227 | name: 'Systolic blood pressure',type: TemplateFieldType.FLOAT, unit: 'mmHg')) |
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228 | .addToFields(new TemplateField( |
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229 | name: 'Diastolic blood pressure',type: TemplateFieldType.FLOAT, unit: 'mmHg')) |
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230 | .addToFields(new TemplateField( |
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231 | name: 'Heart rate',type: TemplateFieldType.FLOAT, unit: 'beats/min')) |
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232 | .addToFields(new TemplateField( |
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233 | name: 'Run-in-food',type: TemplateFieldType.TEXT)) |
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234 | .with { if (!validate()) { errors.each { println it} } else save()} |
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235 | |
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236 | |
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237 | // Human sample template |
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238 | def humanSampleTemplate = new Template( |
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239 | name: 'Human tissue sample', entity: dbnp.studycapturing.Sample) |
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240 | .addToFields(new TemplateField( |
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241 | name: 'Description',type: TemplateFieldType.TEXT)) |
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242 | .addToFields(new TemplateField( |
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243 | name: 'SampleType',type: TemplateFieldType.STRING)) |
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244 | .addToFields(new TemplateField( |
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245 | name: 'SampleProtocol',type: TemplateFieldType.STRING)) |
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246 | .addToFields(new TemplateField( |
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247 | name: 'Text on vial',type: TemplateFieldType.STRING)) |
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248 | .with { if (!validate()) { errors.each { println it} } else save()} |
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249 | |
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250 | //events |
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251 | def eventDiet = new EventDescription( |
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252 | name: 'Diet treatment', |
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253 | description: 'Diet treatment (fat percentage)', |
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254 | classification: treatmentTerm, |
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255 | protocol: dietProtocol, |
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256 | isSamplingEvent: false |
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257 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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258 | |
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259 | def eventBoost = new EventDescription( |
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260 | name: 'Boost treatment', |
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261 | description: 'Boost treatment (leptin or vehicle)', |
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262 | classification: treatmentTerm, |
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263 | protocol: boostProtocol, |
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264 | isSamplingEvent: false |
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265 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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266 | |
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267 | def samplingEvent = new EventDescription( |
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268 | name: 'Liver extraction', |
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269 | description: 'Liver sampling for transcriptomics arrays', |
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270 | protocol: liverSamplingProtocol, |
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271 | isSamplingEvent: true |
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272 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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273 | |
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274 | def bloodSamplingEventDescription = new EventDescription( |
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275 | name: 'Blood extraction', |
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276 | description: 'Blood extraction targeted at lipid assays', |
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277 | protocol: bloodSamplingProtocol, |
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278 | isSamplingEvent: true |
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279 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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280 | |
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281 | |
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282 | def fastingTreatment = new EventDescription( |
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283 | name: 'Fasting treatment', |
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284 | description: 'Fasting Protocol NuGO PPSH', |
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285 | protocol: fastingProtocol, |
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286 | isSamplingEvent: false |
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287 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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288 | |
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289 | println('Adding PPS3 study...') |
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290 | |
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291 | // studies |
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292 | def exampleStudy = new Study( |
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293 | template: studyTemplate, |
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294 | title:"NuGO PPS3 mouse study leptin module", |
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295 | code:"PPS3_leptin_module", |
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296 | researchQuestion:"Leptin etc.", |
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297 | description:"C57Bl/6 mice were fed a high fat (45 en%) or low fat (10 en%) diet after a four week run-in on low fat diet. After 1 week 10 mice that received a low fat diet were given an IP leptin challenge and 10 mice of the low-fat group received placebo injections. The same procedure was performed with mice that were fed the high-fat diet. After 4 weeks the procedure was repeated. In total 80 mice were culled.", |
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298 | ecCode:"2007117.c", |
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299 | startDate: Date.parse('yyyy-MM-dd','2007-12-11') |
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300 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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301 | |
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302 | def evLF = new Event( |
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303 | startTime: Date.parse('yyyy-MM-dd','2008-01-07'), |
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304 | endTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
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305 | eventDescription: eventDiet, |
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306 | parameterStringValues: ['Diet':'10% fat (palm oil)'] |
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307 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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308 | |
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309 | def evHF = new Event( |
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310 | startTime: Date.parse('yyyy-MM-dd','2008-01-07'), |
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311 | endTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
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312 | eventDescription: eventDiet, |
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313 | parameterStringValues: ['Diet':'45% fat (palm oil)'] |
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314 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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315 | |
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316 | def evBV = new Event( |
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317 | startTime: Date.parse('yyyy-MM-dd','2008-01-07'), |
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318 | endTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
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319 | eventDescription: eventBoost, |
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320 | parameterStringValues: ['Compound':'Vehicle'] |
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321 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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322 | |
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323 | def evBL = new Event( |
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324 | startTime: Date.parse('yyyy-MM-dd','2008-01-07'), |
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325 | endTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
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326 | eventDescription: eventBoost, |
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327 | parameterStringValues: ['Compound':'Leptin'] |
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328 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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329 | |
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330 | def evLF4 = new Event( |
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331 | startTime: Date.parse('yyyy-MM-dd','2008-01-07'), |
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332 | endTime: Date.parse('yyyy-MM-dd','2008-02-04'), |
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333 | eventDescription: eventDiet, |
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334 | parameterStringValues: ['Diet':'10% fat (palm oil)'] |
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335 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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336 | |
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337 | def evHF4 = new Event( |
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338 | startTime: Date.parse('yyyy-MM-dd','2008-01-07'), |
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339 | endTime: Date.parse('yyyy-MM-dd','2008-02-04'), |
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340 | eventDescription: eventDiet, |
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341 | parameterStringValues: ['Diet':'45% fat (palm oil)'] |
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342 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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343 | |
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344 | def evBV4 = new Event( |
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345 | startTime: Date.parse('yyyy-MM-dd','2008-01-07'), |
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346 | endTime: Date.parse('yyyy-MM-dd','2008-02-04'), |
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347 | eventDescription: eventBoost, |
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348 | parameterStringValues: ['Compound':'Vehicle'] |
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349 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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350 | |
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351 | def evBL4 = new Event( |
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352 | startTime: Date.parse('yyyy-MM-dd','2008-01-07'), |
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353 | endTime: Date.parse('yyyy-MM-dd','2008-02-04'), |
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354 | eventDescription: eventBoost, |
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355 | parameterStringValues: ['Compound':'Leptin'] |
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356 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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357 | |
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358 | def evS = new SamplingEvent( |
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359 | startTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
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360 | endTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
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361 | eventDescription: samplingEvent, |
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362 | parameterFloatValues: ['Sample weight':5F] |
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363 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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364 | |
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365 | def evS4 = new SamplingEvent( |
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366 | startTime: Date.parse('yyyy-MM-dd','2008-02-04'), |
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367 | endTime: Date.parse('yyyy-MM-dd','2008-02-04'), |
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368 | eventDescription: samplingEvent, |
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369 | parameterFloatValues: ['Sample weight':5F] |
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370 | ).with { if (!validate()) { errors.each { println it} } else save()} |
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371 | |
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372 | // Add events to study |
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373 | exampleStudy |
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374 | .addToEvents(evLF) |
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375 | .addToEvents(evHF) |
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376 | .addToEvents(evBV) |
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377 | .addToEvents(evBL) |
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378 | .addToEvents(evLF4) |
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379 | .addToEvents(evHF4) |
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380 | .addToEvents(evBV4) |
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381 | .addToEvents(evBL4) |
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382 | .addToSamplingEvents(evS) |
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383 | .addToSamplingEvents(evS4) |
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384 | .save() |
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385 | |
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386 | def LFBV1 = new EventGroup(name:"10% fat + vehicle for 1 week") |
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387 | .addToEvents(evLF) |
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388 | .addToEvents(evBV) |
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389 | .with { if (!validate()) { errors.each { println it} } else save()} |
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390 | |
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391 | def LFBL1 = new EventGroup(name:"10% fat + leptin for 1 week") |
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392 | .addToEvents(evLF) |
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393 | .addToEvents(evBL) |
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394 | .with { if (!validate()) { errors.each { println it} } else save()} |
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395 | |
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396 | def HFBV1 = new EventGroup(name:"45% fat + vehicle for 1 week") |
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397 | .addToEvents(evHF) |
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398 | .addToEvents(evBV) |
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399 | .with { if (!validate()) { errors.each { println it} } else save()} |
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400 | |
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401 | def HFBL1 = new EventGroup(name:"45% fat + leptin for 1 week") |
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402 | .addToEvents(evHF) |
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403 | .addToEvents(evBL) |
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404 | .with { if (!validate()) { errors.each { println it} } else save()} |
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405 | |
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406 | def LFBV4 = new EventGroup(name:"10% fat + vehicle for 4 weeks") |
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407 | .addToEvents(evLF4) |
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408 | .addToEvents(evBV4) |
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409 | .with { if (!validate()) { errors.each { println it} } else save()} |
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410 | |
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411 | def LFBL4 = new EventGroup(name:"10% fat + leptin for 4 weeks") |
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412 | .addToEvents(evLF4) |
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413 | .addToEvents(evBL4) |
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414 | .with { if (!validate()) { errors.each { println it} } else save()} |
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415 | |
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416 | def HFBV4 = new EventGroup(name:"45% fat + vehicle for 4 weeks") |
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417 | .addToEvents(evHF4) |
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418 | .addToEvents(evBV4) |
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419 | .with { if (!validate()) { errors.each { println it} } else save()} |
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420 | |
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421 | def HFBL4 = new EventGroup(name:"45% fat + leptin for 4 weeks") |
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422 | .addToEvents(evHF4) |
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423 | .addToEvents(evBL4) |
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424 | .with { if (!validate()) { errors.each { println it} } else save()} |
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425 | |
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426 | // Add subjects and samples and compose EventGroups |
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427 | |
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428 | def x=1 |
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429 | 80.times { |
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430 | def currentSubject = new Subject( |
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431 | name: "A" + x++, |
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432 | species: mouseTerm, |
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433 | template: mouseTemplate, |
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434 | ) |
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435 | .setFieldValue("Gender", "Male") |
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436 | .setFieldValue("Genotype", "C57/Bl6j") |
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437 | .setFieldValue("Age (weeks)", 17) |
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438 | .setFieldValue("Cage", "" + (int)(x/2)) |
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439 | .with { if (!validate()) { errors.each { println it} } else save()} |
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440 | |
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441 | exampleStudy.addToSubjects(currentSubject) |
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442 | .with { if (!validate()) { errors.each { println it} } else save()} |
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443 | |
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444 | // Add subject to appropriate EventGroup |
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445 | if (x > 70) { HFBL4.addToSubjects(currentSubject).save() } |
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446 | else if (x > 60) { HFBV4.addToSubjects(currentSubject).save() } |
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447 | else if (x > 50) { LFBL4.addToSubjects(currentSubject).save() } |
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448 | else if (x > 40) { LFBV4.addToSubjects(currentSubject).save() } |
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449 | else if (x > 30) { HFBL1.addToSubjects(currentSubject).save() } |
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450 | else if (x > 20) { HFBV1.addToSubjects(currentSubject).save() } |
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451 | else if (x > 10) { LFBL1.addToSubjects(currentSubject).save() } |
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452 | else { LFBV1.addToSubjects(currentSubject).save() } |
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453 | |
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454 | } |
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455 | |
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456 | // Add EventGroups to study |
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457 | exampleStudy |
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458 | .addToEventGroups(LFBV1) |
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459 | .addToEventGroups(LFBL1) |
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460 | .addToEventGroups(HFBV1) |
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461 | .addToEventGroups(HFBL1) |
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462 | .addToEventGroups(LFBV4) |
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463 | .addToEventGroups(LFBL4) |
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464 | .addToEventGroups(HFBV4) |
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465 | .addToEventGroups(HFBL4) |
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466 | .save() |
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467 | |
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468 | println 'Adding PPSH study' |
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469 | |
---|
470 | def humanStudy = new Study( |
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471 | template: studyTemplate, |
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472 | title:"NuGO PPS human study", |
---|
473 | code:"PPSH", |
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474 | researchQuestion:"How much are fasting plasma and urine metabolite levels affected by prolonged fasting ?", |
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475 | description:"Human study", |
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476 | ecCode:"unknown", |
---|
477 | startDate: Date.parse('yyyy-MM-dd','2009-01-01') |
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478 | ).with { if (!validate()) { errors.each { println it} } else save()} |
---|
479 | |
---|
480 | def fastingEvent = new Event( |
---|
481 | startTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
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482 | endTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
---|
483 | eventDescription: fastingTreatment, |
---|
484 | parameterStringValues: ['Fasting period':'8h']); |
---|
485 | |
---|
486 | def bloodSamplingEvent = new SamplingEvent( |
---|
487 | startTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
---|
488 | endTime: Date.parse('yyyy-MM-dd','2008-01-14'), |
---|
489 | eventDescription: bloodSamplingEventDescription, |
---|
490 | parameterFloatValues: ['Sample volume':4.5F]); |
---|
491 | |
---|
492 | def rootGroup = new EventGroup(name: 'Root group'); |
---|
493 | rootGroup.addToEvents fastingEvent |
---|
494 | rootGroup.addToEvents bloodSamplingEvent |
---|
495 | rootGroup.save() |
---|
496 | |
---|
497 | def y = 1 |
---|
498 | 11.times { |
---|
499 | def currentSubject = new Subject( |
---|
500 | name: "" + y++, |
---|
501 | species: humanTerm, |
---|
502 | template: humanTemplate).setFieldValue("Gender", (boolean) (x / 2) ? "Male" : "Female").setFieldValue("DOB", new java.text.SimpleDateFormat("dd-mm-yy").parse("01-02-19" + (10 + (int) (Math.random() * 80)))).setFieldValue("Age (years)", 30).setFieldValue("Height", Math.random() * 2F).setFieldValue("Weight (kg)", Math.random() * 150F).setFieldValue("BMI", 20 + Math.random() * 10F).with { if (!validate()) { errors.each { println it} } else save()} |
---|
503 | |
---|
504 | rootGroup.addToSubjects currentSubject |
---|
505 | rootGroup.save() |
---|
506 | |
---|
507 | def currentSample = new Sample( |
---|
508 | name: currentSubject.name + '_B', |
---|
509 | material: bloodTerm, |
---|
510 | parentSubject: currentSubject, |
---|
511 | parentEvent: bloodSamplingEvent); |
---|
512 | |
---|
513 | |
---|
514 | humanStudy.addToSubjects(currentSubject).addToSamples(currentSample).with { if (!validate()) { errors.each { println it} } else save()} |
---|
515 | } |
---|
516 | |
---|
517 | humanStudy.addToEventGroups rootGroup |
---|
518 | humanStudy.save() |
---|
519 | |
---|
520 | // Add clinical data |
---|
521 | |
---|
522 | def lipidAssay = new dbnp.clinicaldata.ClinicalAssay( |
---|
523 | name: 'Lipid profile', |
---|
524 | approved: true |
---|
525 | ).with { if (!validate()) { errors.each { println it} } else save()} |
---|
526 | |
---|
527 | def ldlMeasurement = new dbnp.clinicaldata.ClinicalMeasurement( |
---|
528 | name: 'LDL', |
---|
529 | unit: 'mg/dL', |
---|
530 | type: dbnp.data.FeatureType.QUANTITATIVE, |
---|
531 | referenceValues: '100 mg/dL', |
---|
532 | detectableLimit: 250, |
---|
533 | isDrug: false, isIntake: true, inSerum: true |
---|
534 | ).with { if (!validate()) { errors.each { println it} } else save()} |
---|
535 | |
---|
536 | def hdlMeasurement = new dbnp.clinicaldata.ClinicalMeasurement( |
---|
537 | name: 'HDL', |
---|
538 | unit: 'mg/dL', |
---|
539 | type: dbnp.data.FeatureType.QUANTITATIVE, |
---|
540 | referenceValues: '50 mg/dL', |
---|
541 | detectableLimit: 100, |
---|
542 | isDrug: false, isIntake: true, inSerum: true |
---|
543 | ).with { if (!validate()) { errors.each { println it} } else save()} |
---|
544 | |
---|
545 | lipidAssay.addToMeasurements ldlMeasurement |
---|
546 | lipidAssay.addToMeasurements hdlMeasurement |
---|
547 | |
---|
548 | def lipidAssayInstance = new dbnp.clinicaldata.ClinicalAssayInstance( |
---|
549 | assay: lipidAssay |
---|
550 | ).with { if (!validate()) { errors.each { println it} } else save()} |
---|
551 | |
---|
552 | humanStudy.samples*.each { |
---|
553 | new dbnp.clinicaldata.ClinicalFloatData( |
---|
554 | assay: lipidAssayInstance, |
---|
555 | measurement: ldlMeasurement, |
---|
556 | sample: it.name, |
---|
557 | value: Math.round(Math.random()*ldlMeasurement.detectableLimit) |
---|
558 | ).with { if (!validate()) { errors.each { println it} } else save()} |
---|
559 | |
---|
560 | new dbnp.clinicaldata.ClinicalFloatData( |
---|
561 | assay: lipidAssayInstance, |
---|
562 | measurement: hdlMeasurement, |
---|
563 | sample: it.name, |
---|
564 | value: Math.round(Math.random()*hdlMeasurement.detectableLimit) |
---|
565 | ).with { if (!validate()) { errors.each { println it} } else save()} |
---|
566 | } |
---|
567 | |
---|
568 | // Add assay to study capture module |
---|
569 | |
---|
570 | def clinicalModule = new AssayModule( |
---|
571 | name: 'Clinical data', |
---|
572 | type: AssayType.CLINICAL_DATA, |
---|
573 | platform: 'clinical measurements', |
---|
574 | url: 'http://localhost:8080/gscf' |
---|
575 | ).with { if (!validate()) { errors.each { println it} } else save()} |
---|
576 | |
---|
577 | def lipidAssayRef = new Assay( |
---|
578 | name: 'Lipid profiling', |
---|
579 | module: clinicalModule, |
---|
580 | externalAssayId: lipidAssayInstance.id |
---|
581 | ).with { if (!validate()) { errors.each { println it} } else save()} |
---|
582 | |
---|
583 | humanStudy.samples*.each { |
---|
584 | lipidAssayRef.addToSamples(it) |
---|
585 | } |
---|
586 | lipidAssayRef.save() |
---|
587 | |
---|
588 | humanStudy.addToAssays(lipidAssayRef); |
---|
589 | humanStudy.save() |
---|
590 | |
---|
591 | } |
---|
592 | } |
---|
593 | |
---|
594 | def destroy = { |
---|
595 | } |
---|
596 | } |
---|