Welcome to project Diagnostic Variant Database (DVD)

Coordinated by the NBIC Bio-Assist program, several groups from Dutch University Medical Centers (LUMC, UMCU, UMCN, UMCG) launched a nation-wide human genomic variant database, the Diagnostic Variant Database (DVD). The purpose is to share all genetic variants detected in the course of next-generation sequencing (NGS) applications between collaborators. This will help medical researchers to distinguish between functionally relevant and benign genetic variants. Therefore, researchers or clinicians can quickly narrow down to those variants that are the potential genetic cause of a particular disease. DVD also allows users to contact the researcher who originally identified a particular genetic mutation. This makes DVD a platform where new research collaboration can be established.

New members are welcome to this shared and closed infrastructure. Please contact the DVD administration team (​dvd-admin) for any membership or technical questions. For more technical information about DVD, see the documentation page. Also see the changelog for release information

Data Access Policy

DVD is a closed system and its content is only available to registered users. Please read the data access policy on how to use DVD.

Source Code Access

DVD uses the source code developed for project ​Varda.

Advisory Committee

• Johan den Dunnen (LUMC)
• Jeroen Laros (LUMC)
• Joris Veltman (UMCN)
• Morris Swertz (UMCG)
• Edwin Cuppen (Hubrecht/UMCU)
• Victor Guryev (UMCG)

DVD Administration Team

• Jeroen Laros (LUMC)
• Martijn Vermaat (LUMC)
• Christian Gilissen (UMCN)
• Pieter Neerincx (UMCG)
• Wim Spee (Hubrecht/UMCU)
• Ies Nijmans (Hubrecht/UMCU)
• David van Enckevort (NBIC)
• Leon Mei (NBIC)

Other NBIC software projects

All active NBIC software projects can be accessed from the ​project index.