1 | package nl.tno.metagenomics.integration |
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2 | |
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3 | |
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4 | import grails.converters.* |
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5 | import nl.tno.metagenomics.Study |
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6 | import org.codehaus.groovy.grails.commons.ConfigurationHolder |
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7 | |
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8 | /** Expose the list of features within a certain assay |
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9 | * |
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10 | * @author Robert Horlings (robert@isdat.nl) |
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11 | * @since 20101229 |
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12 | * @see SAM.RestController |
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13 | * |
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14 | * $Rev$ |
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15 | * |
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16 | * This class provides a REST-full service for getting and setting the data |
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17 | * in the Metagenomics Module. The service consists of several |
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18 | * resources listed below. So far, all resources are GET resoruces, i.e. we |
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19 | * do not use PUT, POST or DELETE. Because we are using Grails' web libaries, |
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20 | * each resource corresponds to exactly one action of this controller. |
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21 | * |
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22 | * |
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23 | * The REST resources implemented in this controller are: |
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24 | * |
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25 | * metagenomics-host:port/metagenomics/rest/getMeasurements(assayToken) |
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26 | * metagenomics-host:port/metagenomics/rest/getMeasurementMetadata(assayToken, measurementTokens) |
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27 | * metagenomics-host:port/metagenomics/rest/getMeasurementData(assayToken, measurementTokens, sampleTokens) |
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28 | * metagenomics-host:port/metagenomics/rest/getAssayURL(assayToken) |
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29 | * |
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30 | * Where 'metagenomics-host' is the url of the metagenomics server's host with port number 'port'. |
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31 | * |
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32 | */ |
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33 | class RestController { |
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34 | def synchronizationService |
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35 | |
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36 | /****************************************************************/ |
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37 | /* REST resources for providing basic data to the GSCF */ |
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38 | /****************************************************************/ |
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39 | private getMeasurementTypes() { |
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40 | return [ "# sequences", "average quality" ] |
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41 | } |
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42 | |
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43 | /** |
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44 | * Return a list of simple assay measurements matching the querying text. |
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45 | * |
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46 | * @param assayToken |
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47 | * @return list of measurements for token. Each member of the list is a hash. |
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48 | * the hash contains the three keys values pairs: value, sampleToken, and |
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49 | * measurementMetadata. |
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50 | * |
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51 | * Example REST call: |
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52 | * http://localhost:8184/metagenomics/rest/getMeasurements/query?assayToken=16S-5162 |
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53 | * |
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54 | * Resulting JSON object: |
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55 | * |
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56 | * [ "# sequences", "average quality" ] |
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57 | * |
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58 | */ |
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59 | def getMeasurements = { |
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60 | def assayToken = params.assayToken; |
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61 | |
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62 | if( !checkAssayToken( assayToken ) ) { |
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63 | response.sendError(404) |
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64 | return false |
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65 | } |
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66 | |
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67 | render getMeasurementTypes() as JSON |
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68 | } |
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69 | |
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70 | |
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71 | /** |
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72 | * Return measurement metadata for measurement |
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73 | * |
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74 | * @param assayToken |
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75 | * @param measurementTokens. List of measurements for which the metadata is returned. |
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76 | * If this is not given, then return metadata for all |
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77 | * measurements belonging to the specified assay. |
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78 | * @return list of measurements |
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79 | * |
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80 | * Example REST call: |
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81 | * http://localhost:8184/metagenomics/rest/getMeasurementMetadata/query?assayToken=16S-5162 |
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82 | * &measurementToken=# sequences |
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83 | * &measurementToken=average quality |
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84 | * |
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85 | * Example resulting JSON object: |
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86 | * |
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87 | * [ {"name":"# sequences","type":"raw"}, |
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88 | * {"name":"average quality", "unit":"Phred"} ] |
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89 | */ |
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90 | def getMeasurementMetadata = { |
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91 | def assayToken = params.assayToken |
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92 | def measurementTokens = params.measurementToken |
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93 | |
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94 | if( !checkAssayToken( assayToken ) ) { |
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95 | response.sendError(404) |
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96 | return false |
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97 | } |
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98 | |
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99 | // For now, we don't have any metadata about the measurements |
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100 | def measurements = getMeasurementTypes(); |
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101 | def measurementMetadata = [] |
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102 | |
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103 | measurementTokens.each { token -> |
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104 | if( measurements.contains( token ) ) |
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105 | measurementMetadata << [ "name" : token ]; |
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106 | } |
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107 | |
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108 | render measurementMetadata as JSON |
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109 | } |
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110 | |
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111 | |
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112 | /* |
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113 | * Return list of measurement data. |
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114 | * |
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115 | * @param assayTokes |
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116 | * @param measurementToken. Restrict the returned data to the measurementTokens specified here. |
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117 | * If this argument is not given, all samples for the measurementTokens are returned. |
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118 | * Multiple occurences of this argument are possible. |
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119 | * @param sampleToken. Restrict the returned data to the samples specified here. |
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120 | * If this argument is not given, all samples for the measurementTokens are returned. |
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121 | * Multiple occurences of this argument are possible. |
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122 | * @param boolean verbose. If this argument is not present or it's value is true, then return |
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123 | * the date in a redundant format that is easier to process. |
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124 | * By default, return a more compact JSON object as follows. |
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125 | * |
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126 | * The list contains three elements: |
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127 | * |
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128 | * (1) a list of sampleTokens, |
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129 | * (2) a list of measurementTokens, |
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130 | * (3) a list of values. |
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131 | * |
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132 | * The list of values is a matrix represented as a list. Each row of the matrix |
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133 | * contains the values of a measurementToken (in the order given in the measurement |
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134 | * token list, (2)). Each column of the matrix contains the values for the sampleTokens |
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135 | * (in the order given in the list of sampleTokens, (1)). |
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136 | * (cf. example below.) |
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137 | * |
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138 | * |
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139 | * @return table (as hash) with values for given samples and measurements |
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140 | * |
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141 | * |
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142 | * List of examples. |
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143 | * |
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144 | * |
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145 | * Example REST call: |
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146 | * http://localhost:8184/metagenomics/rest/getMeasurementData/doit?assayToken=PPSH-Glu-A |
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147 | * &measurementToken=total carbon dioxide (tCO) |
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148 | * &sampleToken=5_A |
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149 | * &sampleToken=1_A |
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150 | * &verbose=true |
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151 | * |
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152 | * Resulting JSON object: |
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153 | * [ {"sampleToken":"1_A","measurementToken":"total carbon dioxide (tCO)","value":28}, |
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154 | * {"sampleToken":"5_A","measurementToken":"total carbon dioxide (tCO)","value":29} ] |
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155 | * |
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156 | * |
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157 | * |
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158 | * Example REST call without sampleToken, without measurementToken, |
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159 | * and with verbose representation: |
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160 | * http://localhost:8184/metagenomics/rest/getMeasurementData/dossit?assayToken=PPSH-Glu-A |
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161 | * &verbose=true |
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162 | * |
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163 | * Resulting JSON object: |
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164 | * [ {"sampleToken":"1_A","measurementToken":"sodium (Na+)","value":139}, |
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165 | * {"sampleToken":"1_A","measurementToken":"potassium (K+)","value":4.5}, |
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166 | * {"sampleToken":"1_A","measurementToken":"total carbon dioxide (tCO)","value":26}, |
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167 | * {"sampleToken":"2_A","measurementToken":"sodium (Na+)","value":136}, |
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168 | * {"sampleToken":"2_A","measurementToken":"potassium (K+)","value":4.3}, |
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169 | * {"sampleToken":"2_A","measurementToken":"total carbon dioxide (tCO)","value":28}, |
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170 | * {"sampleToken":"3_A","measurementToken":"sodium (Na+)","value":139}, |
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171 | * {"sampleToken":"3_A","measurementToken":"potassium (K+)","value":4.6}, |
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172 | * {"sampleToken":"3_A","measurementToken":"total carbon dioxide (tCO)","value":27}, |
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173 | * {"sampleToken":"4_A","measurementToken":"sodium (Na+)","value":137}, |
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174 | * {"sampleToken":"4_A","measurementToken":"potassium (K+)","value":4.6}, |
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175 | * {"sampleToken":"4_A","measurementToken":"total carbon dioxide (tCO)","value":26}, |
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176 | * {"sampleToken":"5_A","measurementToken":"sodium (Na+)","value":133}, |
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177 | * {"sampleToken":"5_A","measurementToken":"potassium (K+)","value":4.5}, |
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178 | * {"sampleToken":"5_A","measurementToken":"total carbon dioxide (tCO)","value":29} ] |
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179 | * |
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180 | * |
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181 | * |
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182 | * Example REST call with default (non-verbose) view and without sampleToken: |
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183 | * |
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184 | * Resulting JSON object: |
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185 | * http://localhost:8184/metagenomics/rest/getMeasurementData/query? |
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186 | * assayToken=PPSH-Glu-A& |
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187 | * measurementToken=total carbon dioxide (tCO) |
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188 | * |
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189 | * Resulting JSON object: |
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190 | * [ ["1_A","2_A","3_A","4_A","5_A"], |
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191 | * ["sodium (Na+)","potassium (K+)","total carbon dioxide (tCO)"], |
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192 | * [139,136,139,137,133,4.5,4.3,4.6,4.6,4.5,26,28,27,26,29] ] |
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193 | * |
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194 | * Explanation: |
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195 | * The JSON object returned by default (i.e., unless verbose is set) is an array of three arrays. |
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196 | * The first nested array gives the sampleTokens for which data was retrieved. |
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197 | * The second nested array gives the measurementToken for which data was retrieved. |
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198 | * The thrid nested array gives the data for sampleTokens and measurementTokens. |
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199 | * |
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200 | * |
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201 | * In the example, the matrix represents the values of the above Example and |
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202 | * looks like this: |
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203 | * |
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204 | * 1_A 2_A 3_A 4_A 5_A |
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205 | * |
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206 | * Na+ 139 136 139 137 133 |
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207 | * |
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208 | * K+ 4.5 4.3 4.6 4.6 4.5 |
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209 | * |
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210 | * tCO 26 28 27 26 29 |
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211 | * |
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212 | */ |
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213 | def getMeasurementData = { |
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214 | def assayToken = params.assayToken |
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215 | def measurementTokens = params.measurementToken |
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216 | def sampleTokens = params.sampleToken |
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217 | def verbose = false |
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218 | |
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219 | if(params.verbose && (params.verbose=='true'||params.verbose==true) ) { |
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220 | verbose=true |
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221 | } |
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222 | |
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223 | def assay = checkAssayToken( assayToken ); |
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224 | if( !assay ) { |
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225 | response.sendError(404) |
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226 | return false |
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227 | } |
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228 | |
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229 | if( !measurementTokens ) { |
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230 | measurementTokens = [] |
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231 | } |
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232 | else if( measurementTokens.class == java.lang.String ) { |
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233 | measurementTokens = [ measurementTokens ] |
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234 | } |
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235 | |
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236 | if( !sampleTokens ) { |
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237 | sampleTokens = [] |
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238 | } |
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239 | else if( sampleTokens.class == java.lang.String ) { |
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240 | sampleTokens = [ sampleTokens ] |
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241 | } |
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242 | |
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243 | def data = SampleAssay.findAllByAssay( assay ); |
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244 | def measurements = getMeasurementTypes() |
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245 | |
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246 | def results = [] |
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247 | data.each { sampleAssay -> |
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248 | measurements.each { type -> |
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249 | def sample = sampleAssay.sample.sampleToken |
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250 | def isMatch = false |
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251 | |
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252 | // Check if this measurement should be returned |
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253 | if( ( measurementTokens.isEmpty() || measurementTokens.contains( type ) ) && |
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254 | ( sampleTokens.isEmpty() || sampleTokens.contains( sample ) ) ) { |
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255 | results.push( [ 'sampleToken': sample, 'measurementToken': type, 'value': sampleAssay[ type ] ] ) |
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256 | } |
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257 | } |
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258 | } |
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259 | |
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260 | if(!verbose) { |
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261 | results = compactTable( results ) |
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262 | } |
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263 | |
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264 | render results as JSON |
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265 | } |
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266 | |
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267 | /** |
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268 | * Is called by GSCF when a study is added, changed or deleted. |
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269 | * Sets the 'dirty' flag of a study to true, so that it will be updated |
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270 | * next time the study is asked for. |
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271 | * |
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272 | * @param studyToken |
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273 | */ |
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274 | def notifyStudyChange = { |
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275 | def studyToken = params.studyToken |
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276 | |
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277 | if( !studyToken ) { |
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278 | response.sendError(400, "No studyToken given" ) |
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279 | return |
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280 | } |
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281 | |
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282 | // Search for the changed study |
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283 | def study = Study.findByStudyToken( studyToken ); |
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284 | |
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285 | // If the study is not found, it is added in GSCF. Add a dummy (dirty) study, in order to |
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286 | // update it immediately when asked for |
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287 | if( !study ) { |
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288 | log.info( "METAGENOMICS: GSCF notification for new study " + studyToken ); |
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289 | study = new Study( |
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290 | name: "", |
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291 | studyToken: studyToken, |
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292 | isDirty: true |
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293 | ) |
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294 | } else { |
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295 | log.info( "METAGENOMICS: GSCF notification for existing study " + studyToken ); |
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296 | study.isDirty = true; |
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297 | } |
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298 | study.save(flush:true); |
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299 | |
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300 | def jsonData = [ 'studyToken': studyToken, message: "Notify succesful" ]; |
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301 | |
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302 | render jsonData as JSON |
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303 | } |
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304 | |
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305 | /** |
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306 | * Return URL to view an assay. |
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307 | * |
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308 | * @param assayToken |
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309 | * @return URL to view an assay as single hash entry with key 'url'. |
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310 | * |
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311 | */ |
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312 | def getAssayURL = { |
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313 | def assayToken = params.assayToken |
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314 | |
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315 | if( !assayToken ) { |
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316 | render [] as JSON |
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317 | return |
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318 | } |
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319 | |
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320 | def assay = Assay.findByAssayToken( assayToken ) |
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321 | |
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322 | // If the assay is not found, try synchronizing |
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323 | synchronizationService.sessionToken = session.sessionToken |
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324 | |
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325 | if( !assay ) { |
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326 | synchronizationService.synchronizeStudies() |
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327 | assay = Assay.findByAssayToken( assayToken ); |
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328 | |
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329 | if( !assay ) { |
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330 | response.sendError(404, "Not Found" ) |
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331 | return; |
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332 | } |
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333 | } else { |
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334 | try { |
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335 | synchronizationService.synchronizeAssay(assay); |
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336 | } catch( Exception e ) { |
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337 | response.sendError( 500, e.getMessage()) |
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338 | return |
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339 | } |
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340 | |
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341 | def url = [ 'url' : ConfigurationHolder.config.grails.serverURL + '/assay/show/' + assay.id.toString() ] |
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342 | |
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343 | render url as JSON |
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344 | } |
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345 | } |
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346 | |
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347 | /***************************************************/ |
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348 | /* REST resources related to the querying in GSCF */ |
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349 | /***************************************************/ |
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350 | |
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351 | /** |
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352 | * @param (no parameters) |
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353 | * @return metadata fields that can be available for any assay stored in the module |
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354 | */ |
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355 | def getAssayMetadataFields = { |
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356 | def exampleType = Assay.find() |
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357 | def list = [] |
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358 | |
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359 | exampleType.giveFields.each{ |
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360 | list.push( it.name ) |
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361 | } |
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362 | |
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363 | render list as JSON |
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364 | } |
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365 | |
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366 | /** |
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367 | * |
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368 | * @param assayToken |
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369 | * @param measurementTokens |
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370 | * @return metadata values for the specified assay |
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371 | */ |
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372 | def getAssayMetadataValues = { |
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373 | def error = CommunicationManager.hasValidParameters( params, 'assayToken' ) |
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374 | if(error) { |
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375 | render error as JSON |
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376 | return |
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377 | } |
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378 | def assay = SimpleAssay.findByExternalAssayID( params.assayToken ) |
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379 | def types = [] |
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380 | def hash = [] |
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381 | token.getMeasurements.each { |
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382 | types.push( it.type ) |
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383 | } |
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384 | types.unique.each { type -> |
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385 | type.fields.each { field -> |
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386 | hash[field.name] = field.value |
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387 | } |
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388 | } |
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389 | render hash as JSON |
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390 | } |
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391 | |
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392 | |
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393 | |
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394 | /** |
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395 | * @param assayToken |
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396 | * @return list of metadata fields that are available for the samples in the specified assay |
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397 | */ |
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398 | def getSampleMetadataFields = { |
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399 | def error = CommunicationManager.hasValidParameters( params, 'assayToken' ) |
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400 | if(error) { |
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401 | render error as JSON |
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402 | return |
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403 | } |
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404 | def assay = SimpleAssay.findByExternalAssayID( params.assayToken ) |
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405 | def types = [] |
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406 | assay.getTypes.each{ |
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407 | types.push(it.name) |
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408 | } |
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409 | render types as JSON |
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410 | } |
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411 | |
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412 | |
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413 | |
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414 | /** |
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415 | * @param assayToken |
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416 | * @param list of sampleTokens |
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417 | * @return List of sample metadata values for the specified samples in the specified assay. |
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418 | * Each element of the list is a hash containing values for one sample. |
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419 | * The hash contains the key "sampleToken" to indentify the sample. The other keys |
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420 | * of the hash contain information on the actual metadata values for the sample. |
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421 | * The keys are metadata fields, the values are the values of the corresponding |
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422 | * SimpleAssayMeasurements. |
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423 | */ |
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424 | def getSampleMetadata = { |
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425 | def error = CommunicationManager.hasValidParameters( params, 'assayToken', 'sampleToken' ) |
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426 | if(error) { |
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427 | render error as JSON |
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428 | return |
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429 | } |
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430 | def assay = SimpleAssay.findByExternalAssayID( params.assayToken ) |
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431 | def samples = [] |
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432 | def list = [] |
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433 | params.sampleToken.each{ |
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434 | if( SimpleAssaySample.findByName(it).assay == assay ) { |
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435 | samples.push(it) |
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436 | } |
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437 | } |
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438 | samples.each{ sample -> |
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439 | def hash = ['sampleToken':sample.name] |
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440 | SimpleAssayMeasurement.findAllBySample(sample).each{ measurement -> |
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441 | hash[measurement.type.name]=measumrent.value |
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442 | } |
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443 | list.push hash |
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444 | } |
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445 | render list as JSON |
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446 | } |
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447 | |
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448 | private def checkAssayToken( def assayToken ) { |
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449 | if( !assayToken || assayToken == null ) { |
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450 | return false |
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451 | } |
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452 | def list = [] |
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453 | def assay = Assay.findByAssayToken( assayToken ) |
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454 | |
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455 | if( !assay || assay == null ) { |
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456 | return false; |
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457 | } |
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458 | |
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459 | return assay; |
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460 | } |
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461 | |
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462 | /* helper function for getSamples |
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463 | * |
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464 | * Return compact JSON object for data. The format of the returned array is as follows. |
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465 | * |
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466 | * The list contains three elements: |
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467 | * |
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468 | * (1) a list of sampleTokens, |
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469 | * (2) a list of measurementTokens, |
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470 | * (3) a list of values. |
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471 | * |
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472 | * The list of values is a matrix represented as a list. Each row of the matrix |
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473 | * contains the values of a measurementToken (in the order given in the measurement |
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474 | * token list, (2)). Each column of the matrix contains the values for the sampleTokens |
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475 | * (in the order given in the list of sampleTokens, (1)). |
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476 | */ |
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477 | def compactTable( results ) { |
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478 | def i = 0 |
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479 | def sampleTokenIndex = [:] |
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480 | def sampleTokens = results.collect( { it['sampleToken'] } ).unique() |
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481 | sampleTokens.each{ sampleTokenIndex[it] = i++ } |
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482 | |
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483 | i = 0 |
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484 | def measurementTokenIndex= [:] |
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485 | def measurementTokens = results.collect( { it['measurementToken'] } ).unique() |
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486 | measurementTokens.each{ measurementTokenIndex[it] = i++ } |
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487 | |
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488 | def data = [] |
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489 | measurementTokens.each{ m -> |
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490 | sampleTokens.each{ s -> |
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491 | def item = results.find{ it['sampleToken']==s && it['measurementToken']==m } |
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492 | data.push item ? item['value'] : null |
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493 | } |
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494 | } |
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495 | |
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496 | return [ sampleTokens, measurementTokens, data ] |
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497 | } |
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498 | |
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499 | } |
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